Human Sera
Cayman Chemical ClofentezIn 50mg
An acaricide; has broad-spectrum activity against various plant-feeding mite species; lethal to wild-type, but not chs1 mutant, T. urticae mite eggs (LC50s = 1.2 and >5,000 mg/L, respectively); induces formation of thyroid tumors in male rats from 13-1,000 mg/kg per day
Cayman Chemical RaltItrexed 100mg
An inhibitor of thymidylate synthase (Ki = 62 nM); inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM); reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model at 4 mg/kg; reduces tumor growth and the number of metastases in an HCT116-luc mouse xenograft model
Cayman Chemical TIrapazamIn 100mg
A hypoxia-activated anticancer agent; is converted to an oxidizing radical under hypoxic conditions; can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity; induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively); induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions; sensitizes tumors to cisplatin in a mouse RIF-1 fibrosarcoma tumor model; sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model at (0.08 mmol/kg)
Cayman Chemical DodecylphosphocholIn-d38 100mg
An internal standard for the quantification of dodecylphosphocholine by GC- or LC-MS
Cayman Chemical PergolIdemesylate 50mg
A dopamine D1 and D2 receptor agonist (Kis = 111 and 0.495 nM, respectively, for rat striatal receptors); depresses dopaminergic firing in paralyzed rats (ED50 = 50 = 0.4 mg/kg)
Cayman Chemical NDemethylvncomycInhydroch 50mg
A glycopeptide antibiotic; active against several strains of S. aureus and S. epidermidis in vitro and in vivo
Cayman Chemical LevobetaxololhydrochLRIde 50mg
A β1-adrenergic receptor antagonist (Ki = 0.76 nM for the human receptor); selective for β1-ARs over β2-ARs (Ki = 32.6 nM), as well as a panel of 89 additional receptors (IC50s = >1 µM); inhibits isoproterenol-induced cAMP production in human non-pigmented ciliary epithelial cells (Ki = 16.4 nM); topical application reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension at 150 UG/eye
Cayman Chemical DIphenylpyralIn 100mg
A histamine H1 receptor antagonist (Ki = 20 nM); inhibits ovalbumin-induced bronchoconstriction in ovalbumin-sensitized guinea pigs at 20 µmol/kg; reduces dopamine uptake in rat nucleus accumbens at 14 mg/kg
Cayman Chemical PhysostIgmInsalIcylate 50mg
An alkaloid and cholinergic agent; inhibits AChE (IC50 = 0.67 nM); inhibits ChE and increases vagal stimulation-induced ACh output in isolated chicken heart at 10 µM; induces decentralized lower eyelid contractions and increases blood pressure in anesthetized rats at 200 and 400 UG/kg
Cayman Chemical Bcuculn 50mg
A competitive GABAA receptor antagonist that at 100 μM blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons; reversibly blocks GABAA receptors on horizontal cells in the mouse retina (IC50 = 1.7 μM); mimics the action of epilepsy and thus used in experimental studies as a convulsant
Cayman Chemical DaunorubIcInon 50mg
An aglcyone form of the antitumor antibiotic daunorubicin; has been used as a starting material in the synthesis of anticancer agents
Cayman Chemical Pnaxatrol 50mg
A sapogenin with diverse biological activities; inhibits the proliferation of human DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of ROS and decreasing mitochondrial membrane potential; reduces ischemia and reperfusion-induced myocardial dysfunction, increases LVDevP and GSH levels, and decreases cardiac LDH, CK, and MDA levels in isolated rats at 5 mg/kg for seven consecutive days prior to injury; decreases fasting blood glucose levels in KKAy insulin-resistant mice at 0.2% in chow for 6 weeks
Cayman Chemical PF-06650833 50mg
An IRAK4 inhibitor (IC50 = 0.2 nM); selective for IRAK4 over a panel of 268 kinases at 200 nM but also inhibits IRAK1, MNK2, LRRK2, Clk4, and CK1γ1 by >70% at 200 nM; reduces DNA secretion from R-837-stimulated primary human neutrophils and decreases R-848-induced IRF5 nuclear translocation in primary human PMBCs at 100 nM; decreases paw volume in a rat model of collagen-induced arthritis at 100 mg/kg once per day; reduces serum levels of anti-dsDNA, anti-SSA, and anti-RNP antibodies and decreases kidney glomerular tuft area in a mouse model of pristane-induced SLE
Cayman Chemical Esaxerenon 100mg
A non-steroidal mineralocorticoid receptor antagonist (IC50 = 9.4 nM); selective for mineralocorticoid receptors over glucocorticoid, androgen, and progesterone receptors (IC50s = >10,000 nM for all); increases the urinary ratio of sodium to potassium in bilateral adrenalectomized rats at 0.3, 1, or 3 mg/kg; decreases systolic blood pressure in DOCA-salt hypertensive rats at 3 mg/kg; reduces systolic blood pressure, urinary protein levels, blood levels of BNP, kidney and left ventricle weights, and glomerulosclerosis, as well as increases blood potassium levels, in Dahl salt-sensitive rats fed a high-salt diet at 2 mg/kg per day